The Endocannabinoid System and its Modulation by Cannabidiol (CBD)

By Jamie Corroon, ND, MPH; Jake F. Felice, ND, LMP

As interest in, and use of, phytocannabinoids from Cannabis Sativa L (Cannabis) has increased with the number of state-regulated Cannabis programs, heightened scientific attention has been directed toward the mechanisms by which delta-9-tetrahydrocannabiniol (delta-9-THC), cannabidiol (CBD), and other phytocannabinoids exert their physiological effects in the body. These exogenous, plant-derived ligands interact with endogenously produced proteins, receptors, enzymes, and endogenous ligands, in one of the most evolutionarily preserved biological systems known to the life sciences, the endogenous cannabinoid signaling system or endocannabinoid system (ECS).

The ECS is thought to be 600-million-years-old. Present in every animal species, except insects, it evolved as a stress/ harm regulation network that functions to restore homeostasis following cellular stressors. The ECS is up-regulated and down-regulated on a continuous basis as needed. It communicates with all other systems in the body and has been implicated in multiple regulatory functions in both health and disease, including pain, perception, mood, memory, and reward.2,3 This vital physiological system is modulated by diet, sleep, exercise, stress, and a multitude of other factors, including exposure to phytocannabinoids.

According to George Kunos, Scientific Director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) at the National Institutes of Health (NIH), “Modulating endocannabinoid system activity may have therapeutic potential in almost all diseases affecting humans.”


This CBD Study was authored by Jamie Corroon, the Medical Director at the Center for Medical Cannabis Education, a for-profit, clinical practice and research and consulting entity, and Jake F. Felice, principal of Cannabis Matrix Consulting, a for-profit consulting entity. 


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